| ncRNA name | RAGE siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal Müller cell line MIO-M1 |
| Methods | immunofluorescence, siRNA transfection, qRT-PCR, ELISA, Western blot |
| Expression pattern | associated |
| Functional description | Hyperglycaemia in vivo and in vitro exposure to high glucose induce upregulation of RAGE and its ligands, leading to RAGE signalling, which links to pro-inflammatory responses by retinal Müller glia. Blockade of RAGE prevented cytokine responses induced by high glucose and S100B in Müller glia. |
| PubMed ID | 20835858 |
| Year | 2010 |
| Title | Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE). |
| Drug-related ncRNA | NO |
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